Zetpil™ Branched Chain Amino Acid Suppository

• Increase muscle performance and recovery
• Increase protein and muscle synthesis
• Provide essential amino acids directly to muscles

The Zetpil™ Branched Chain Amino Acid contains the essential amino acids leucine, isoleucine and valine, which must be consumed through diet since the human body cannot make them from other compounds. Branched Chain Amino Acids (BCAAs hereafter) make up 35% of the amino acids in muscle proteins and 40% of the essential amino acids required by humans. Research has shown BCAAs to be beneficial for promoting healthy muscle mass, improving overall exercise performance, decreasing fatigue post-training, providing essential nutritional support, and may be important in preventing cancer-induced cachexia.

Zetpil™ Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method.  These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability, and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues. 

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

What Is The Source?

The Branched Chain Amino Acid is ideal for those individuals who wish to maintain a meat- free, vegetarian diet. Isoleucine and valine are produced from corn dextrose fermentation. Leucine is extracted from a variety of protein sources (primarily soybeans) and undergoes extensive processing and purification before achieving its final bioavailable form.

Research-Proven Uses for Branched Chain Amino Acids

Exercise and Training-Related Benefits

“The International Society of Sports Nutrition (ISSN) has concluded that consuming BCAAs (in addition to carbohydrates) before, during, and following an exercise bout would be recommended safe and effective”, in part for the reasons described below.  ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853497/}

Branched Chain Amino Acids may play a role in athletic support by:

• promoting muscle nitrogen,
• enhancing alanine and glutamine production,
• decreasing lactate production,
• moderating central nervous system fatigue thereby supporting mental performance, and 
• boosting energy while decreasing protein breakdown= increased muscle work capacity and recovery.

“Branched Chain Amino Acids (BCAA) conserve muscle mass and indeed, studies examining recovery from heavy endurance activity have shown evidence that BCAA are beneficial in reducing muscle damage (ie: soreness) and accelerating the recovery process.”  Prior experiments “showed that amino acid supplementation was effective in reducing muscle damage and soreness when consumed immediately before and during the four recovery days that followed a damaging bout of exercise.” ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395580/}

“Branched-chain amino acids (valine, leucine, and isoleucine; BCAAs) help to inhibit protein breakdown and enhance protein synthesis. BCAAs have been reported in many studies to attenuate delayed onset muscle soreness (DOMS) and muscle damage induced by exercise.” ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827986/}

“It is clear that exercise promotes degradation of BCAAs and yet muscle-protein synthesis is enhanced after exercise. Therefore BCAA supplementation before and after exercise has beneficial effects for decreasing exercise-induced muscle damage and promoting muscle-protein synthesis.”

^{http://jn.nutrition.org/content/134/6/1583S.abstract}

Cancer Cachexia

Cachexia is clinically recognized as unintentional, progressive weight loss and wasting of muscle tissue caused both by the natural course of the disease as well as a serious side effect from current medical treatments. Branched chain amino acids may be beneficial for the prevention and/or treatment of cancer-induced cachexia, a condition experienced by 50%-80% of all cancer patients and is a significant risk factor for treatment failure, toxicity and shorter survival.  In fact, cachexia kills up to 25% of cancer patients regardless of diagnosis or treatment success. ^{http://www.ncbi.nlm.nih.gov/pubmed/15213711}

Commonly Megastrol acetate (Megace) is prescribed and is used as an appetite stimulant which acts to suppress some inflammatory conditions believed to be partly responsible for this condition. Unfortunately, Megace, like other pharmaceutical options, has numerous side effects, some severe and potentially life threatening.   

“Megace has not shown promise in increasing lean body mass or markers of protein metabolism in the cachectic cancer patient.”^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016925/}

Liver Cirrhosis

“Cirrhosis is a slowly progressing disease in which healthy liver tissue is replaced with scar tissue, eventually preventing the liver from functioning properly. The scar tissue blocks the flow of blood through the liver and slows the processing of nutrients, hormones, drugs, and naturally produced toxins. It also slows the production of proteins and other substances made by the liver.” ^{http://www.webmd.com/digestive-disorders/cirrhosis-liver}   

Therefore, diseases affecting the liver (ie: Hepatitic C, fatty liver, alcohol abuse) drastically affect a person’s nutrient status.  These nutrient deficiencies can cause muscle weakness, fatigue, fluid retention, jaundice and overall diminished quality of life (QOL).

Since “serum concentrations of BCAAs are decreased in patients with advanced liver diseases, several clinical trials have suggested that Branched Chain Amino Acid (BCAA) supplementation improves the prognosis of cirrhotic patients (by, but not limited to)”:

• improving protein malnutrition and nutritional status in patients;
• reducing the frequency of albumin infusion in children with end-stage liver disease;
• reducing oxidative stress by reducing iron accumulation;
• attenuating fibrosis; and
• improving glucose metabolism.

^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837260/}

^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723692/}

Supplement Facts

This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).

Warnings:

• If pregnant or lactating, consult your physician before taking this product
• Keep out of reach of children
• Do not exceed recommended dose
• For topical use only
• Avoid eyes and mucous membranes

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a substitute for sound medical advice.