Zetpil™ 98 % Trans-RESVERATROL Suppository


  • Powerful antioxidant properties, including its ability to influence a variety of free radical-associated diseases and normal aging.
  • Clinically proven to be helpful with diabetes, arthritis, cancer, and neurodegenerative diseases
  • May support the cardiovascular system by promoting blood vessel health
  • Resveratrol shows neuro-protectant effects on many of the complex mechanisms contributing to Alzheimer’s disease.

Zetpil™ Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method.  These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability , and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues. 

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

What makes the Zetpil™ trans-Resveratrol Different?

Zetpil™ trans-Resveratrol is unique because it represents the marriage of science and reality.  By embracing the physical properties of resveratrol (low oral bioavailability), the researchers and scientists at Zetpil™ conceived that an alternative delivery method may increase the levels of resveratrol one could achieve over a longer period of time.  Based on research-proven concepts of absorption-enhancing natural compounds, excipients, therapeutically effective dosages and state-of-the-art production methods, Zetpil™ has formulated a resveratrol product which is cost-effective, safe, non-competitive, avoids enzymatic breakdown in the stomach and liver and is patient-friendly.  The science indicates one must absorb approximately 40mg/kg/day of body weight to achieve the predictable therapeutic benefits of resveratrol.  The Zetpil™ trans- resveratrol suppository offers the health-conscious consumer the opportunity to potentially meet those levels. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204008/

What is Reservatrol?

Resveratrol (3,5,4′-trihydroxystilbene), harvested from the roots of Polygonum Cupsidatum, is a polyphenol found in various berries, nuts, and other plant sources. Resveratrol is a phytoalexin (anti-microbial and antioxidative compound), synthesizedby plants during environmental stress and pathogenic invasion, thereby acting as a natural inhibitor of cell proliferation.

Revered for its health benefits since ancient times, Resveratrol began its more recent rise to fame in the 1990s with the coining of the “French Paradox”, the observation that French people have low risk of coronary artery disease despite consuming red wine along with a high fat diet.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348475/ 

Resveratrol is primarily available in its trans– form because this is the form most studied and recognized for powerful antioxidant properties, including its ability to influence a variety of “oxidative stress-associated diseases”. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713511/  Resveratrol has shown to be effective for:

  • Immune function,
  • Longevity (anti-aging),
  • Heart disease,
  • Neurologic disorders,
  • Metabolic disorders, and
  • Degenerative conditions.


The PROPAGANDA of Resveratrol

Understanding the pharmacology (the branch of medicine and biology concerned with the study of drug action) of natural compounds requires some time and effort.  Research, from all over the world, spanning decades tells us the therapeutic properties of resveratrol cannot be realized when taken orally.  Yet we are constantly bombarded by nutritional companies, health gurus and the media alike preaching the benefits and anti-aging properties of resveratrol from a bottle.  So, what’s the truth?

  • “It is clear that only a small fraction of the ingested resveratrol reaches the body tissues as resveratrol. The low doses of resveratrol observed in the plasma after ingestion are worrisome, as the concentrations used in a number of in vitrostudies are not reached in humans due to rapid metabolism.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348475/
  • “Resveratrol’s extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1% .Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly.” http://www.ncbi.nlm.nih.gov/pubmed/21261636

The quote below highlights the discrepancy in people’s understanding between dosage levels needed for disease PREVENTION and disease TREATMENT:

  • “even when a very large dose (2.5 and 5 g=2,500-5,000mg) was given as an uncoated pill (orally), the concentration of resveratrol in blood failed to reach the level claimed to be necessary for systemic cancer prevention.”http://www.ncbi.nlm.nih.gov/pubmed/17548692

Ignoring the physical and absorption properties of resveratrol will not make them go away.  Many people are looking to achieve more optimal health with natural products proven to be beneficial in many ways.  By not addressing the major limitations of oral delivery many people are given a false sense of security thinking they are receiving the health benefits of resveratrol when they simply are not.

To aid the patient population in understanding this fundamental issue, imagine you, as a consumer, try to purchase $500.00 worth of groceries for $5.00.  It’s impossible.  Similarly, it is impossible to expect an oral resveratrol dosage of 500mg to provide any health benefits at 5mg (1% bioavailability of resveratrol). The pharmacological dosages used in the research (50mg/kg/day) are both cost-prohibitive and impossible to achieve with the bioavailability issues with oral delivery.

Resveratrol’s Therapeutic Properties

ANTI-AGING: The potential of trans-Resveratrol for anti-aging has been linked to its ability to activate the Sirt1 gene, which is linked to cellular life-span extension. Resveratrol’s antioxidant actions have been shown to decrease mitochondrial production of reactive oxygen species (ROS), which is important because mitochondrial dysfunction and excessive ROS (leading to oxidative damage) lies at the heart of the aging process.

CARDIOVASCULAR HEALTH: Resveratrol has been shown to have strong antioxidant properties and can inhibit platelet aggregation (blood thinning property), a known risk factor for heart attacks and strokes.

CANCER: Resveratrol possesses strong anti-proliferative properties and may act to induce apoptosis (cell death) in many cancer cell lines as well as decrease treatment-induced side effects and enhance current anti-cancer therapies.

NEUROLOGIC CONDITIONS: Resveratrol has neuro-protectant properties and may help protect nerve cells from damage as well as inhibit the buildup of plague that can lead to Alzheimer’s and other neurodegenerative diseases (i.e. Parkinson’s, multiple sclerosis).

DIABETES: Scientific evidence has shown that resveratrol induces favorable changes in diabetic patients.  Resveratrol may be able to induce changes in gene expressions, enzyme activities, decrease cytokine action (pro-inflammatory responses) as well as possibly reduce the pancreatic oxidative damage caused by diabetes.



Supplement Facts

Serving Size:  1 suppository


Servings per Container:  30

Each Zetpil™ Resveratrol 98% contains the following ingredients:


441 mgs Resveratrol 3,5,4′-trihydroxy-trans-stilbenea, natural phenol,  from 450 mgs of polygonum cuspidatum

Suppository Base: The base is a proprietary combination of excipients of plant and fruit butters, medium chain triglycerides, phospholipids, lecithin and arrow root starch.


If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).


  • Although safe for children, this product should be kept out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
  • This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.

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