- Powerful antioxidant against free radical damage
- May help normalize blood glucose levels
- May support reducing anxiety and seizures by modulating GABA receptors
- May help activate PPAR, which has been clinically shown to be helpful in treating Alzheimer’s disease (AD)
- May be a safe adjunctive therapy during cancer treatments
Zetpil Suppository Advantage
Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method. These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.
Additionally, many raw materials simply have a very low bioavailability , and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues.
Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.
What is Honokiol?
Honokiol is a small molecule polyphenol from Magnolia grandiflora which has been shown to have antioxidative, anti-inflammatory, anti-tumor, anti-diabetic, anti-microbial, anti-neurodegeneration, and anti-depressant properties. Honokiol easily moves across the blood brain barrier making it an attractive compound for brain cancers and neurodegenerative diseases.
Honokiol has also been shown to have potent analgesic (pain relief) properties. Its anti-inflammatory properties have shown tremendous benefit for inflammatory disorders like rheumatoid arthritis, psoriasis, inflammatory bowel disease and asthma. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765942/
Honokiol’s Therapeutic Properties
“Many drugs used clinically to treat anxiety, insomnia, and seizures act by enhancing GABAergic neurotransmission, and honokiol has been shown to bind to and positively modulate GABAA receptors.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652012/
“In spite of being effective in normalization of blood glucose levels (Type II Diabetes), the currently used PPARγ agonists from the thiazolidinedione type have serious side effects, making the discovery of novel ligands highly relevant. Honokiol has been demonstrated to improve blood glucose levels and reduce weight gain in diabetic animal models.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212005/
“It is our view that PPAR activation remains a promising avenue for the treatment for Alzheimer’s disease (AD). However, the poor blood brain barrier (BBB) permeability of the currently available agonists and the negative outcome of the phase III clinical trials are likely to diminish interest in pursuing this target.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156324/
Yet, we have safe natural compounds (ie: Honokiol) which have proven their effectiveness in clinical research to be able to effectively modulate the PPAR pathway. As there are no currently effective pharmacological treatments for the prevention and/or treatment of Alzheimer’s disease, Honokiol may represent a promising new therapy to reduce the consequences of neurodegenerative diseases.
“Honokiol has been shown to reverse the multidrug resistance gene, and perhaps the ABCC transporter gene, the two major mechanisms for drug efflux. The (other) major role of honokiol may be facilitating the efficacy of conventional chemotherapy, by inhibiting NF-kB.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842137/
“The use of natural products has been a successful approach towards managing (cancer), and the present review discusses the accumulating literature on the anti-tumor activity of honokiol against various malignancies. Honokiol may:
- inhibit the production of numerous cytokines, inducible enzymes, and adhesion molecules associated with tumor initiation, promotion, progression, metastasis and therapy-resistance.
- target chemopreventive and therapeutic pathways, such as NF-κB, STAT3, EGFR, mTOR and MAPK.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663139/
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